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There is a question that arises once you start talking about reprogramming neurons. If you could wind back the biological clock of a neuron - strip away the accumulated epigenetic damage, restore its youthful gene expression - would you also erase the information it carries? Would you lose the memory encoded in that cell?

This is not an abstract philosophical worry. It is an engineering challenge for anyone who wants to rejuvenate the brain. Unlike a liver or a patch of skin, the brain is not a generic tissue. It stores who you are. Every approach to neuronal reprogramming must thread a needle: make the cell younger without making it forget.

Two recent studies* now suggest this needle can be threaded - and they do so from complementary directions that together paint a more complete picture than either offers alone.

* Several other recent rodent studies, using less memory-targeted designs, point in the same direction: partial reprogramming can improve cognition and/or blunt neurodegeneration signals in the brain.